Aseptic loosening attributed to cement fracture and the subsequent disruption of fixation interfaces remains a major long-term failure mode of cemented arthroplasty. Knowledge of the fracture strength of bone cement, especially in fatigue, is an important indicator of cement integrity and the potential for fixation failure. Several manufacturers have advocated mixing devices to increase the strength of bone cement by reducing its porosity or pore diameter. This study evaluates different mixing methodologies as they influence cement porosity and the diametral tensile strength of cement specimens in both single cycle and fatigue. This serves as a means of establishing the effectiveness of these methods in producing optimal bone cement for use in joint arthroplasty.